Recombinant Human TGF-β1 （mammalian derived）Catalog Number:100-21Synonyms:Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factorDescription:The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Human TGF-β1 is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.AA Sequence:ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CSSource:
HEK293 cellsPurity:Greater than 98% by SDS-PAGE gel and HPLC analyses.Biological Activity:TheED
50was determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10
7units/mg.Cross Reactivity:Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat, Human, Mink, Donkey, N/AResearch Interests:
| Angiogenesis/ Cardiovascular | | Apoptosis |
| Cancer | | Immune System |
| Inflammation | | Proliferation |
| Stem Cells & Differentiation | | TGF-β Superfamily |
| Wound Healing | | Allergy |
Country of Origin:USA
?
Bio-Rad伯樂官網 |伯樂授權代理 |伯樂ddPCR| 伯樂Aminex| 伯樂層析填料色譜柱是專業的授權總代理區域代理經銷平臺。
? 如需詢價，請加客服QQ：1749072012 、客服微信：jinshanbio，或發送郵件到1749072012@qq.com
? 平臺為生命科學研究相關領域提供一站式耗材試劑儀器解決方案和采購服務，數據資源基于CC協議。
? 本文地址：
http://www.yeybxjkgt.cn/thread-47545.htm
特別聲明：以上內容(如有圖片亦包括在內)來源于授權廠家或網絡，如有侵權，請聯系客服刪除，本平臺不提供信息校正和存儲服務。
Notice: The content above (including the pictures if any)comes from authorized manufacturers or networks. In case of infringement, please contact to delete it. This platform does not provide information storage services.
QQ:1749072012