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Anti-PTPN11PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-PTPN11 Polyclonal Antibody品牌：solarbio | 貨號：K008230P

英文名稱Anti-PTPN11 Polyclonal Antibody
宿主Rabbit
別名CFC;NS1;SHP2;BPTP3;PTP2C;PTP-1D;SH-PTP2;SH-PTP
應用WB IHC
稀釋比例WB 1:200-1000. IHC 1:25-100.
交叉反應 Human Mouse Rat
蛋白分子量68kDa
Gene ID5781
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human PTPN11
性狀液體
Public Immunogen RangeRecombinant protein of human PTPN11
Subcellular LocationsCytoplasm
Swiss ProtQ06124
克隆類型 Polyclonal Antibody
背景資料The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

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