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Anti-WISP2PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-WISP2 Polyclonal Antibody品牌：solarbio | 貨號：K007978P

英文名稱Anti-WISP2 Polyclonal Antibody
宿主Rabbit
別名CCN5;CT58;CTGF-L
應用IHC
稀釋比例IHC 1:30-150.
交叉反應 Human
蛋白分子量27/23kDa
Gene ID8839
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human WISP2
性狀液體
Public Immunogen RangeA synthetic peptide of human WISP2
Subcellular LocationsSecreted
Swiss ProtO76076
克隆類型 Polyclonal Antibody
背景資料This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

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