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Anti-RFX5PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-RFX5 Polyclonal Antibody品牌：solarbio | 貨號：K004902P

英文名稱Anti-RFX5 Polyclonal Antibody
宿主Rabbit
別名RFX5
應(yīng)用WB IF
稀釋比例WB 1:500-2000. IF 1:50-100.
交叉反應(yīng) Human
蛋白分子量65kDa
Gene ID5993
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human RFX5
性狀液體
Public Immunogen RangeRecombinant protein of human RFX5
Subcellular LocationsNucleus
Swiss ProtP48382
克隆類型 Polyclonal Antibody
背景資料A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.

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