Anti-MC1RPolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-MC1R Polyclonal Antibody品牌：solarbio | 貨號：K007529P| 英文名稱 | Anti-MC1R Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | CMM5;MSH-R;SHEP2 |
| 應用 | WB |
| 稀釋比例 | WB 1:500-2000. |
| 交叉反應 | Human Mouse |
| 蛋白分子量 | 35kDa |
| Gene ID | 4157 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human MC1R |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human MC1R |
| Swiss Prot | Q01726 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. |
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