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Anti-MC1RPolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-MC1R Polyclonal Antibody品牌：solarbio | 貨號：K007529P

英文名稱Anti-MC1R Polyclonal Antibody
宿主Rabbit
別名CMM5;MSH-R;SHEP2
應用WB
稀釋比例WB 1:500-2000.
交叉反應 Human Mouse
蛋白分子量35kDa
Gene ID4157
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human MC1R
性狀液體
Public Immunogen RangeA synthetic peptide of human MC1R
Swiss ProtQ01726
克隆類型 Polyclonal Antibody
背景資料This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

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