Anti-DUSP4PolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-DUSP4 Polyclonal Antibody品牌：solarbio | 貨號：K008150P| 英文名稱 | Anti-DUSP4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | TYP;HVH2;MKP2;MKP-2 |
| 應用 | WB IHC |
| 稀釋比例 | WB 1:500-2000. IHC 1:50-150. |
| 交叉反應 | Human Mouse Rat |
| 蛋白分子量 | 43kDa |
| Gene ID | 1846 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human DUSP4 |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human DUSP4 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q13115 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. |
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