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Anti-DLATPolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-DLAT Polyclonal Antibody品牌：solarbio | 貨號：K004409P

英文名稱Anti-DLAT Polyclonal Antibody
宿主Rabbit
別名DLTA;PDC-E2;PDCE2
應用WB IF
稀釋比例WB 1:500-2000. IF 1:20-50.
交叉反應 Human Mouse Rat
蛋白分子量69kDa
Gene ID1737
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human DLAT
性狀液體
Public Immunogen RangeRecombinant protein of human DLAT
Subcellular LocationsMitochondrion matrix
Swiss ProtP10515
克隆類型 Polyclonal Antibody
背景資料This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

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