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Anti-HFE2PolyclonalAntibody-一抗-抗體-蛋白與免疫

2023-10-29

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Anti-HFE2 Polyclonal Antibody品牌：solarbio | 貨號：K003928P

英文名稱Anti-HFE2 Polyclonal Antibody
宿主Rabbit
別名HFE2A;HJV;JH;RGMC
應用WB
稀釋比例WB 1:500-2000.
交叉反應 Human Rat
蛋白分子量45kDa
Gene ID148738
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human HFE2
性狀液體
Public Immunogen RangeRecombinant protein of human HFE2
Subcellular LocationsCell membrane GPI-anchor Lipid-anchor
Swiss ProtQ6ZVN8
克隆類型 Polyclonal Antibody
背景資料The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5′ UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

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